Wednesday 17th May

15.00 Registration opens

17.00 Plenary & presentation of the Martin Lackmann Award for Translational Research

SPONSORED BY: MONASH BDI

CHAIR: Roger Daly

Fabienne Mackay

“Targetting the BAFF receptor TACI in Chronic Lymphocyte Leukaemia”

18.00 Conference dinner

Thursday 18th May

8.45 Cancer and Metabolism

SPONSORED BY: MONASH BIOCHEMISTRY & MOLECULAR BIOLOGY

CHAIR: Tony Tiganis

8:45 Andrew Cox

The Hippo-Yap pathway regulates anabolic glucose metabolism to support organ growth

9:10 Mark Febbraio

The engineered designer cytokine IC7 protects against obesity-induced metabolic disease

9:35 Nicholas Clemons

Mutant p53 impairs glutathione synthesis via suppression of the glutamate/cysteine exchanger, xCT: a potential Achilles heel.

10:00 Short talk: Lorraine O’Reilly

NF- k B1 loss incites gastric cancer by immune inflammatory mechanisms

10.15 Morning tea

10:45 Therapeutic targeting of inflammation/immunotherapy

SPONSORED BY: IAN POTTER FOUNDATION

CHAIR: Irina Caminschi

10:45 International: Jen Morton

“Targeting Myeloid Cell Signalling - Therapeutic Strategies for Pancreatic Cancer”

11:25 Phil Darcy

New strategies for enhancing CAR T cell therapy for cancer

11:50 Kate Stacey

TLR4 antagonists in treatment of dengue virus infection

12:15 Short talk: David Gallego-Ortega

Novel immunotherapy approaches in luminal ER+ breast cancer

12.30 Lunch

13.30 Inflammation and pathogenesis

CO-SPONSORS: BIO-RAD / MONASH BIOCHEMISTRY & MOLECULAR BIOLOGY

CHAIR: Richard Berry

13:30 Ashley Mansell

Temporal targeting of the NLRP3 inflammasome demonstrates the therapeutic pitfalls of good and bad inflammation during viral challenge

13:55 Ilia Voskoboinik

Cytotoxic lymphocyte deficiency and susceptibility to cancer

14:20 Sandra Nicholson

SOCS protein regulation of NK cell-mediated tumor immunity

14:45 Short talk: Philippe Boulliet

Complex regulation of TNF expression through its 3’ untranslated region

15:00 Short talk: Christian Doerig

Signalome-wide assessment of host cell response to intracellular pathogens: a source of novel targets for anti-infectives

15.15 Afternoon tea

15.45 Cellular regulators of inflammation:

CO-SPONSORS: GENESEARCH / MONASH BIOCHEMISTRY & MOLECULAR BIOLOGY

CHAIR: Sandra Nicholson

15:45 Stuart Pitson

Targeting the sphingosine kinases in inflammation and cancer

16:10 Meredith O’Keeffe

Dendritic cells & interferon-lambda

16:35 Colby Zaph

Epigenetic Regulation of Immunity and Inflammation

17:00 Short talk: Michael Gantier

The importance of the cGAS pathway in DNA damage-driven inflammation

17:15 Short talk: Andrew Ellisdon

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

17.30 Poster Session & Wine Tasting

19.00 BBQ dinner

Friday 19th May

8:30 Inflammation and cancer progression/metastasis

SPONSOR: AB CAM / TECAN

CHAIR: Mike Rogers

8:30 Erica Sloan

Targeting a neural-inflammatory signalling axis to stop metastasis

8:55 Belinda Parker

Turning up the heat on breast cancer to prevent metastasis

9:20 Matthias Ernst

Mast cells and Macrophages as therapeutic target for gastrointestinal

cancers

9:45 Short talk: Mary Vail

Therapeutic targeting or modulation of EphA3 in the inflammatory tumor microenvironment inhibits cancer growth

10:00 Short talk: Claire Vennin

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

10.15 Poster Prize Announcement followed by morning tea

10:45 Signaling/Transcription and Inflammation

SPONSOR: BMG LABTECH

CHAIR: Steven Gerondakis

10:45 Shaun McColl

A new paradigm in chemokine receptor-mediated regulation of the type 17

immune response

11:10 Paul Hertzog

Regulating the inflammatory actions of type I interferons: from receptors to

ISGs

11:35 John Silke

Beware the MLKL, the jaws that bite: Uffish thoughts on the role of

necroptosis and inflammation

12:00 Short talk: Martin Stone

Key Determinants of Differential Signalling at Chemokine Receptors

12:15 Short talk: Ashleigh Morgan

Targeting the Src/JAK/STAT3 signalling pathway: A novel and promising therapeutic strategy for pancreatic cancer

12.30 Lunch

13.30 Inflammation & cell death

SPONSOR: IAN POTTER FOUNDATION

CHAIR: Lan Nguyen

13:30 Short talk: Thomas Naderer

Preventing inflammation and infections by inducing apoptosis

13:45 Marc Pellegrini

Understanding and harnessing endogenous TNF’s therapeutic potential

14:10 Ben Kile

Caspases, mitochondrial DNA and DAMP signalling

14:30 International: Manolis Pasparakis

“The interplay between IKK/NF-kB and RIPK1 signalling in cell death and inflammation”

15.10 Closing remarks

15.30 Conference end and farewell

15.45 Bus departure



Attendees are advised to book flights from Melbourne Airport that leave at 19.00 or later.

Download a copy of the schedule here.

© 2016 Monash University